Endocrine Abstracts

Introduction: Anemia is defined by the World Health Organization as a hemoglobin concentration less than 120 g/l in women outside of pregnancy, and less than 130 g/l in men over 15 years of age. It is common in diabetics. It can be due to an autoimmune disease associated with type 1 diabetes, whereas the inflammatory cause is the primary cause in type 2 diabetes.Observation: This is a 75 year old patient, type 2 diabetic for 21 years on insulin analogues...

Background and aim: Non-diabetic hypoglycemia is a rare entity that regroups several pathologies. Its exact diagnosis is mostly challenging. Endogenous hyperinsulinism is a curable cause that should be thoroughly screened. The objective of our study was to analyze the ethipathological aspects of hypoglycemia by endogenous hyperinsulinism.Patients and methods: We conducted a retrospective study at the Endocrinology department of Hedi Chaker University Hos...

Background and aim: Acromegaly is a rare condition caused by an excessive secretion of growth hormone (GH) and insulin-like growth factor1 (IGF-1), which are responsible for exaggerated somatic growth and cardiometabolic disturbances. This study aims to describe the ophthalmologic complications seen in acromegaly.Patients and Methods : We conducted a retrospective study (1997-2020) at the Endocrinology department of Hedi Chaker University Hospital, Sfax,...

Objective: To describe the phenotypic and molecular characteristics of familial thyroid dyshormonogenesis (FTDH) in the Tunisian population.Patients and Methods: A retrospective descriptive study including two related (R and K) with high consanguinity whose members are carriers of FTDH. Biological and genetic screening was proposed for all consenting members.Results: FTDH was identified in 11 patients (8 girls, 3 boys) with a mean ...

Background and aim: Hyperthyroidism status can be complicated by polymorphic neuromuscular manifestations sometimes revealing. In the majority of cases, these disorders regress during the transition to euthyroidism. We report in this work 6 observations illustrating the neuromuscular manifestations seen in hyperthyroidism.Observations: We report two cases of chronic myopathy: a man and a woman aged 47 and 55 years respectively, hospitalized for hyperthyr...

The autoimmune thyroid disease (AITDs) comprises two clinical phenotype, Graves’ disease (GD) and autoimmune hypothyroidism (AIH), which include goitrous [Hashimoto thyroiditis (HT)] and non goitrous forms [Primary idiopathic myxoedema (PIM)]. These disorders are characterized by loss of immunological self tolerance including the presence of a thyroid lymphocytic infiltrate and autoantibodies to thyroglobulin (Tg) and thyroid peroxidase (TPO). Inheritance of AITDs is comp...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant disorder caused by mutations in the MEN1 tumor suppressor gene and is characterized clinically by tumors in two or more endocrine glands, such as the pituitary gland, parathyroid glands or pancreatic islets. We describe an atypical presentation of familial hyperparathyroidism evoking the diagnosis of MEN1 in the first place.Observations: We report a three-member family....

Intoduction: Pitiutary tumor is considered as the first etiology responsable of secondary hypopituitarism. Hypogonadotropic hypogonadism is the most commonly reported lesion.Meterials and methods: It is a retrospective study including 77 cases of prolactinoma. The data collection was done over 17 years, between 2000 and 2017.Results: Gonadotropic deficiency was confirmed in 48 patients (63.6%). A significant negative correlation wa...

Introduction: The non-functional pituitary adenoma (NFPA) is a benign tumor, which has a progressive development but it is a severe tumor by its neuro-ophthalmological and endocrine repercussions.Patients and methods: It is about a descriptive and retrospective study conducted in 35 patients collected in the endocrinology department of Sfax between January 2000 and December 2017. The diagnosis of NFPA was based on the presence of pituitary adenoma on hyp...

Introduction: The metabolic stressor, hypoglycemia, elicits integrated counterregulatory responses, including activation of the hypothalamic–pituitary–adrenal axis. However, it is suggested that recurring insulin-induced hypoglycemia can impair this counter-regulation. Here we report three cases of patients with isulinoma and corticotroph deficiency.Case reports: The first case, 38-year-old man was referred because of recurrent episode...